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Two-dimensional geometric template diffusion for boosting single-sequence protein structure prediction

Nature Machine Intelligenceby Zheng, WenmingApril 1, 20267 min read1 views
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Nature Machine Intelligence, Published online: 01 April 2026; doi:10.1038/s42256-026-01210-2 Wang et al. introduce TDFold, which reformulates 3D protein structure prediction as a 2D image-like diffusion task. Its geometric template diffusion framework offers greater accuracy, speed and efficiency than leading models.

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Nature Machine Intelligence

https://www.nature.com/articles/s42256-026-01210-2
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