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Training mRNA Language Models Across 25 Species for $165

Reddit r/LocalLLaMAby /u/dark-night-rises https://www.reddit.com/user/dark-night-risesMarch 31, 20261 min read1 views
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<table> <tr><td> <a href="https://www.reddit.com/r/LocalLLaMA/comments/1s912ur/training_mrna_language_models_across_25_species/"> <img src="https://external-preview.redd.it/nVu8HcAwsZ22nurNc_vAW-R_2drotHTdQavTOwGgmi4.png?width=640&amp;crop=smart&amp;auto=webp&amp;s=00c766290f7df67dcd9c20ff789b8f25a14b886b" alt="Training mRNA Language Models Across 25 Species for $165" title="Training mRNA Language Models Across 25 Species for $165" /> </a> </td><td> <!-- SC_OFF --><div class="md"><p>We built an end-to-end protein AI pipeline covering structure prediction, sequence design, and codon optimization. After comparing multiple transformer architectures for codon-level language modeling, CodonRoBERTa-large-v2 emerged as the clear winner with a perplexity of 4.10 and a Spearman CAI correlation of 0

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